Publications by authors named "A R Floreani"
Article Synopsis
- The study looked at how patients with a liver disease called primary biliary cholangitis (PBC) respond to a treatment called ursodeoxycholic acid (UDCA).
- It found that many patients (33%) didn’t have a good response after one year, and those who lost their good response had a higher chance of needing a liver transplant or dying.
- The research showed that staying or getting back to a good response is important for improving long-term health.
Dynamics of Liver Stiffness Measurement and Clinical Course of Primary Biliary Cholangitis.
Clin Gastroenterol Hepatol
December 2024
Article Synopsis
- The study investigates the prognostic value of changes in liver stiffness measurement (LSM) over time in patients with primary biliary cholangitis (PBC) who are being treated with ursodeoxycholic acid.
- It utilizes data from 3,078 patients over a 19-year period, finding that 59% of participants had an increase in LSM, which is linked to a higher risk of serious clinical events such as cirrhosis complications and liver transplants.
- The research concludes that monitoring LSM changes provides essential prognostic information, suggesting its potential as a valuable endpoint in clinical trials for PBC treatment.
Background & Aims: Recurrent primary biliary cholangitis (rPBC) develops in approximately 30% of patients and negatively impacts graft and overall patient survival after liver transplantation (LT). There is a lack of data regarding the response rate to ursodeoxycholic acid (UDCA) in rPBC. We evaluated a large, international, multi-center cohort to assess the performance of PBC scores in predicting the risk of graft and overall survival after LT in patients with rPBC.
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- The study focused on creating a scoring system called the OCA response score (ORS) to predict how individuals with primary biliary cholangitis (PBC) will respond to the treatment using obeticholic acid (OCA).
- Data were collected from two large cohorts in Italy to derive and validate the score, which includes various clinical factors both before and after six months of treatment.
- The scoring system demonstrated good predictive ability for treatment response, which could help healthcare providers customize therapies for patients with PBC more effectively.
Gender Medicine has had an enormous expansion over the last ten years. Autoimmune liver diseases include several conditions, i.e.
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