Publications by authors named "A R FURGIUELE"
Article Synopsis
- Proinflammatory cytokines significantly increase the expression and activity of the enzyme indoleamine 2,3-dioxygenase-1 (IDO-1), which plays a key role in regulating T cell responses by converting tryptophan into L-kynurenine in dendritic cells and monocytes.
- An experimental setup involving isolated peripheral blood mononuclear cells (PBMCs) from healthy donors was used to assess IDO1's influence on lymphocyte proliferation under a pro-inflammatory environment triggered by lipopolysaccharide and anti-CD3/CD28.
- Results showed that while increased IDO1 activity correlated with reduced lymphocyte proliferation when tryptophan was introduced, inhibiting IDO1 did not affect
Article Synopsis
- Cannabidiol (CBD) is studied for its impact on immune responses, specifically how it influences proinflammatory cytokine production and T cell behavior in human peripheral blood mononuclear cells (PBMCs).
- The research analyzed CBD's effects on cytokine levels, cell proliferation, and regulatory T cell functionality, using techniques like flow cytometry and ELISA assays on isolated cells from healthy individuals.
- Results indicate that CBD decreases certain cytokine mRNA levels and alters T cell differentiation, but its role in Treg cell function and PBMC proliferation is complex, warranting further exploration.
Article Synopsis
- Parkinson's disease (PD) impacts 7-10 million people globally, with no existing treatments to halt or slow down its progression, largely due to a lack of understanding about how dopaminergic neuron death occurs.
- Current treatments mainly aim to compensate for dopamine deficiency in the brain but don't adequately address the underlying disease mechanisms.
- Recent research highlights the immune system's role in PD, suggesting that targeting immune pathways could improve treatment outcomes alongside existing dopaminergic therapies.
Background: Dysregulation of the CD4 + T cell compartment occurs in Parkinson's Disease (PD). Nonetheless, the exact relationship with dopamine transporter (DAT) SPECT denervation patterns is currently unknown.
Methods: Expression of transcription factors and levels of circulating CD4 + T cell subsets were assessed in peripheral blood mononuclear cells (PBMC) from 23 newly diagnosed drug-naïve PD patients.
Parkinson's disease (PD) is a neurodegenerative disease caused by loss of dopaminergic neurons in the midbrain. PD is clinically characterized by a variety of motor and nonmotor symptoms, and treatment relies on dopaminergic replacement. Beyond a common pathological hallmark, PD patients may present differences in both clinical progression and response to drug therapy that are partly affected by genetic factors.
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