Publications by authors named "A R FRISK"
Sharing pathology data is critical for educational and scientific purposes. Since most pharmaceutical or (agro)chemical companies outsource nonclinical safety assessment studies to contract research organizations (CROs), the pathology data of those studies are not owned by the investigator but is the legal property of the respective company sponsoring the work. Although some companies have installed policies that govern sharing of pathology data, many companies generally do not allow the external use of data by either the CRO-based study pathologist or the sponsor pathologist.
View Article and Find Full Text PDFWe demonstrate magnetic droplet soliton pairs in all-perpendicular spin-torque nano-oscillators (STNOs), where one droplet resides in the STNO free layer (FL) and the other in the reference layer (RL). Typically, theoretical, numerical, and experimental droplet studies have focused on the FL, with any additional dynamics in the RL entirely ignored. Here we show that there is not only significant magnetodynamics in the RL, but the RL itself can host a droplet driven by, and coexisting with, the FL droplet.
View Article and Find Full Text PDFArticle Synopsis
- A lot of new ideas have been created in the last 10 years to help reduce the use of animals in testing new medicines, with a cool new idea called Virtual Control Groups (VCGs).
- The paper talks about the challenges of using VCGs, especially in studying body tissues, and mentions that scientists and regulators need to work together to make this happen smoothly.
- They suggest that to prove VCGs really work, tests should be done with both VCGs and standard control groups at the same time, and later they could even replace the use of real animals in some cases!
Article Synopsis
- Small intestinal vacuolation caused by the compound HAP-1 was seen in rats but not in dogs, despite higher drug exposure in dogs.
- Rats consistently exhibited epithelial vacuolation at various doses, while dogs only showed temporary vacuolation at specific time points.
- The differences in intestinal response between species were linked to how much HAP-1 and its metabolite accumulated in the intestines, with rats having significantly higher concentrations, leading to lipid metabolism issues and ER stress observed only in rats.
In situ hybridization (ISH) is used for the localization of specific nucleic acid sequences in cells or tissues by complementary binding of a nucleotide probe to a specific target nucleic acid sequence. In the last years, the specificity and sensitivity of ISH assays were improved by innovative techniques like synthetic nucleic acids and tandem oligonucleotide probes combined with signal amplification methods like branched DNA, hybridization chain reaction and tyramide signal amplification. These improvements increased the application spectrum for ISH on formalin-fixed paraffin-embedded tissues.
View Article and Find Full Text PDF