Publications by authors named "A R Clark"
Health and racial disparities can limit access to preventative, trauma, and chronic disease care but have not been addressed in burn resuscitation. Over- and under-resuscitation contribute to increased overall hospital costs, and morbidity and mortality rates. The primary objective of this study was to identify potential racial disparities that may exist during the initial fluid resuscitation after burn injury.
View Article and Find Full Text PDFWith advancements in breast cancer treatment, survivorship has increased, leading to 3.8 million survivors in the US. These women have diverse supportive care needs, often addressed through Survivorship Programs (SPs), which provide clinical and non-clinical support services.
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- The study aims to evaluate the feasibility of an exercise intervention for young people aged 13-17 with mild to moderate depression, comparing high-intensity exercise, low-intensity exercise, and social activities.
- Participants were recruited through mental health services and schools, with the intervention delivered over 12 weeks by trained professionals.
- Results showed a 71.4% retention rate and over 67% attendance, although only 14 participants were randomized from the initial referrals, indicating challenges in recruitment.
Understanding the genomic landscape of breast cancer brain metastases (BCBMs) is key to developing targeted treatments. In this study, targetable genomic profiling was performed on 822 BCBMs, 11,988 local breast cancer (BC) biopsies and 15,516 non-central nervous system (N-CNS) metastases (all unpaired samples) collected during the course of routine clinical care by Foundation Medicine Inc (Boston, MA). Clinically relevant genomic alterations were significantly enriched in BCBMs compared to local BCs and N-CNS metastases.
View Article and Find Full Text PDFChronic pain is a major global concern, with at least 1 in 5 people suffering from chronic pain worldwide. Mounting evidence indicates that neuroplasticity of the anterior cingulate cortex (ACC) is a critical step in the development of chronic pain. Previously, we found that chronic pain and fear learning are both associated with enhanced neuronal excitability and cause similar neuroplasticity-related gene expression changes in the ACC of male mice.
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