Publications by authors named "A R Cenacchi"
Background: Arthroscopic meniscectomy is one of the most performed surgical procedures in orthopaedics. Different approaches have been proposed to improve patient recovery but with unsatisfactory results. Platelet-rich plasma (PRP) augmentation has been proposed as a strategy to improve the recovery after meniscectomy.
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- Platelet-rich plasma (PRP) injections for knee osteoarthritis (OA) are becoming common, but the effect of leukocytes in PRP remains debated, with some studies showing they could be harmful while others suggest they have beneficial roles.
- This study aimed to evaluate the safety and effectiveness of leukocyte-rich PRP (LR-PRP) versus leukocyte-poor PRP (LP-PRP) in treating knee OA through a randomized controlled trial involving 132 patients with varying degrees of OA.
- Results showed improvements in both subjective and objective outcomes for all patients, with LR-PRP demonstrating greater benefits in the IKDC subjective score and range of motion at earlier follow-up points compared to LP-PRP,
Intra-articular injections of autologous platelet concentrates are considered capable to enhance the healing of cartilage lesions, alleviate joint inflammation, and relieve other musculoskeletal pathological conditions. The aim of this study was to analyze the soluble fractions obtained from platelet-rich plasma (pure- and leukocyte-PRP) to compare time- and preparation-dependent modifications of growth factor concentrations and the supporting activity of the two preparations on synovial fibroblast growth and hyaluronic acid (HA) production in vitro. The release kinetics of FGF-2, SDF-1, VEGF, HGF, EGF, PD GF-AB/BB, IGF-1, VCAM-1, and TGF-β isoforms were followed up to 168 h after PRP activation, and their amounts were determined by multiplex-beads immunoassay.
View Article and Find Full Text PDFBackground: Intra-articular microfragmented adipose tissue (MF-AT) injections have been proposed for the treatment of knee osteoarthritis (OA).
Purpose: To compare a single injection of MF-AT or platelet-rich plasma (PRP) in terms of clinical outcomes and OA progression.
Study Design: Randomized controlled trial; Level of evidence, 1.