Publications by authors named "A R Biesbrock"
Objective: To evaluate the exposure frequency effect of 0.454% stannous fluoride (SnF) toothpaste in controlling gingivitis.
Methods: Two randomized controlled trials enrolled generally healthy adults with gingivitis.
Objective: Stannous has been shown to bind to free lipopolysaccharides, thus preventing them from binding to TLR receptors. This study was undertaken to determine the histomorphological mechanism of stannous binding to anaerobic bacteria.
Methods: Two bacteria associated with gingivitis and advanced periodontal disease, () and , were cultured in 25-1,000 μM of stannous fluoride and stannous chloride for 48 h.
Introduction: Results from systematic reviews and meta-analyses show generally consistent antigingivitis effects between 3- and 6-mo observation time points with twice-daily use of stannous fluoride (SnF) dentifrice. However, the relationship between 1-, 3-, and 6-mo gingivitis responses has not been investigated.
Methods: This pooled analysis was conducted to understand the relationship of 1-, 3-, and 6-mo gingival bleeding outcomes.
Purpose: To evaluate the antiplaque effects for 0.454% bioavailable gluconate chelated stannous fluoride (SnF₂) dentifrices versus controls by clinical model, plaque index, tooth surface and tooth type in a pooled analysis.
Methods: Randomized controlled trials (RCTs) were conducted to evaluate plaque effects of SnF₂ dentifrices from the same formulation family over the past 30 years.
Virucidal Activity of Over-the-Counter Oral Care Products Against SARS-CoV-2.
Oral Health Prev Dent
April 2022
Purpose: The oral cavity is an important entry point for SARS-CoV-2 infection. This study tested whether four commercially available mouthrinses and dentifrices have in vitro virucidal activity against SARS-CoV-2 (=4 log10 reduction in viral titer).
Materials And Methods: One part of stock SARS-CoV-2 virus plus one part 0.