Publications by authors named "A R Barker"
Background: Peak oxygen consumption (peak O) is traditionally scaled by body mass, but it is most appropriately scaled by fat-free mass. However, it is unknown whether peak O scaled by fat-free mass is associated with mortality and morbidity in people with a Fontan circulation. The aim of this study was to assess the associations between different expressions of peak O with mortality and morbidity in people with a Fontan circulation.
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- The study aimed to establish reference values for fetal 4D flow MRI and assess its reliability in measuring blood flow in healthy fetuses and those with suspected aortic coarctation (CoA).
- Researchers conducted MRI scans on 34 pregnant patients, collecting data from both healthy fetuses and those with potential cardiovascular issues, analyzing the accuracy and consistency of the flow measurements obtained.
- The results indicated that fetal 4D flow MRI provides reliable hemodynamic measurements with high precision and repeatability, although it tends to underestimate blood flow compared to traditional 2D phase contrast MRI techniques.
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- - The study investigated how levels of sex hormone binding globulin (SHBG) relate to fracture risk in older women, focusing on a group of 4,871 women aged 70 and above who weren't on specific medications.
- - Results showed a positive correlation between higher SHBG levels and increased fracture risk over approximately 3.9 years, with those in the highest SHBG quartile being significantly more at risk compared to the lowest quartile.
- - Although two genetic variants were found to influence SHBG levels, they did not correlate with fracture risk, indicating that the increased fracture risk associated with SHBG was not due to genetic factors.
Mycobacterium abscessus (MAB) is intrinsically resistant to many antibiotics, but the evolution of acquired drug resistance is poorly understood. We analyzed published genomes of 5,617 clinical MAB isolates from 20 countries and searched for signals of ongoing evolution in 35 drug-resistance-associated genes. Of these, we found 14 genes were subject to positive selection and identified novel mutational sites under selection.
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