Investigating the Replacement of Carboxylates with Carboxamides to Modulate the Safety and Efficacy of Platinum(II) Thioether Cyanide Scavengers.

Cyanide represents a persistent threat for accidental or malicious misuse due to easy conversion into a toxic gas and access to large quantities through several industries. The high safety index of hydroxocobalamin is a cornerstone quality as a cyanide scavenger. Unfortunately, intravenous infusion of hydroxocobalamin limits the utility in a mass casualty setting.

[Cardiac rhythm in pupils during tests].

Variation pulsometry was used to study changes in the activity of cardiac rhythm regulating mechanisms in third-form pupils from a comprehensive school (a control group) and a gymnasium (a study group) under mental stress caused by the performance of mathematical tests. Two types of responses of the studied parameters: sympathetic (in the study group) and parasympathetic (in the control group), which were determined by the richness and intensity of an academic load and by the readiness of both categories of school-children, were identified.

Does one size fit all? Drug resistance and standard treatments: results of six tuberculosis programmes in former Soviet countries.

Setting: After the collapse of the Soviet Union, countries in the region faced a dramatic increase in tuberculosis cases and the emergence of drug resistance.

Objective: To discuss the relevance of the DOTS strategy in settings with a high prevalence of drug resistance.

Design: Retrospective analysis of one-year treatment outcomes of short-course chemotherapy (SCC) and results of drug susceptibility testing (DST) surveys of six programmes located in the former Soviet Union: Kemerovo prison, Russia; Abkhasia, Georgia; Nagorno-Karabagh, Azerbaijan; Karakalpakstan, Uzbekistan; Dashoguz Velayat, Turkmenistan; and South Kazakhstan Oblast, Kazakhstan.

[Synaptosomal degradation of neuropeptides].

Proteolytic conversions of some neuropeptides possessing neurotransmitter and neuromodulator properties were studied on the synaptosomal plasma membrane level. The main goal was to describe the peptide bonds being primarily hydrolysed by membrane peptidases. The analysis of the accumulated data allowed one to make some summarizing conclusions about properties of the enzyme system responsible for the biological inactivation of the peptides in synapsis.