Publications by authors named "A R Aref"
The endoplasmic reticulum (ER) is crucial for maintaining calcium balance, lipid biosynthesis, and protein folding. Disruptions in ER homeostasis, often due to the accumulation of misfolded or unfolded proteins, lead to ER stress, which plays a significant role in various diseases, especially cancer. Urological cancers, which account for high male mortality worldwide, pose a persistent challenge due to their incurability and tendency to develop drug resistance.
View Article and Find Full Text PDFAutophagy in cancer development, immune evasion, and drug resistance.
Drug Resist Updat
January 2025
Article Synopsis
- Autophagy is a cellular process that breaks down and recycles components, playing a crucial role in maintaining cell health, but its disruption can lead to diseases like cancer.
- In cancer, autophagy has a dual role; it can act as a tumor suppressor in early stages but may promote tumor growth later, influenced by genetic and environmental factors.
- Targeting autophagy offers a promising approach to overcome chemoresistance in cancer treatment, but this is complicated due to its ability to both help and harm cancer cells, necessitating careful consideration in therapy strategies.
Article Synopsis
- A study evaluated the effectiveness of the Lucidis hybrid intraocular lens in glaucoma patients undergoing cataract surgery and examined contrast sensitivity based on glaucoma control methods.
- The research included 28 patients with early to moderate primary open angle glaucoma, showing significant improvements in various visual acuities and high patient satisfaction (92.9%).
- Results indicated that the type of glaucoma control (medical or surgical) did not significantly impact contrast sensitivity, suggesting the Lucidis IOL is safe and effective for these patients.*
DeePathNet integrates cancer-specific biological pathways using transformer-based deep learning for enhanced cancer analysis. It outperforms existing models in predicting drug responses, cancer types, and subtypes. By enabling pathway-level biomarker discovery, DeePathNet represents a significant advancement in cancer research and could lead to more effective treatments.
View Article and Find Full Text PDFArticle Synopsis
- Resistance to cancer treatments like chemotherapy and immunotherapy poses major challenges in effective patient care.
- Redox homeostasis modification has shown promise in addressing this resistance by altering cellular signaling pathways.
- The study highlights mechanisms such as increased antioxidant activity, drug efflux alterations, and enhanced DNA repair that enable tumor cells to survive treatments, suggesting that better insights into these processes could lead to improved therapy outcomes.