Assessing and Managing Primary Hyperparathyroidism and Fracture Risk in England: A Survey of Medical Professionals.

Purpose: To describe diagnostic approaches and management strategies for patients with primary hyperparathyroidism (PHPT) and recent fracture in England.

Methods: We developed a survey based on a patient at high fracture risk and a new diagnosis of probable PHPT. The survey was circulated among 50 secondary care professionals identified by the Society for Endocrinology Calcium and Bone special interest group.

Investigating Pb2 CAP-binding domain inhibitors from marine bacteria for targeting the influenza A H5N1.

The ongoing increase in the prevalence and mutation rate of the influenza virus remains a critical global health issue. A promising strategy for antiviral drug development involves targeting the RNA-dependent RNA polymerase, specifically the PB2-cap binding domain of Influenza A H5N1. This study employs an in-silico approach to inhibit this domain, crucial for viral replication, using potential inhibitors derived from marine bacterial compounds.

Antibacterial Potential of Honeybee Venom and Extracellular Metabolites Against Multidrug-Resistant Pathogenic Bacteria.

Antimicrobial resistance (AMR) poses a critical global health threat, driving the search for alternative treatments to conventional antibiotics. In this study, the antibacterial properties of honeybee venom (BV) and fungal red dye (RD) were evaluated against three multidrug-resistant bacterial pathogens. Extracts of BV and RD exhibited dose-dependent antibacterial activity against the three tested bacteria, with their strongest effectiveness against (minimum inhibitory concentrations [MIC] = 3.

High-Sensitivity Fluorescent Sensing Platform for Rapid and Selective Detection of Chlorpyrifos Pesticide in Water Samples Using Terbium-Isatin-3-allyl Complex.

The detection of organophosphorus pesticides, particularly chlorpyrifos, in environmental samples is essential due to their widespread use and associated health risks. In this study, we developed a high-sensitivity fluorescent sensing platform utilizing an Isatin-3-allyl-terbium (IS-Tb) complex in solution for the rapid and selective detection of chlorpyrifos in various water samples. The proposed chemical structure of the complex in solution was evaluated using molar ratio method.

Role of Ionizing Radiation Techniques in Polymeric Hydrogel Synthesis for Tissue Engineering Applications.

Hydrogels are widely utilized in industrial and scientific applications owing to their ability to immobilize active molecules, cells, and nanoparticles. This capability has led to their growing use in various biomedical fields, including cell culture and transplantation, drug delivery, and tissue engineering. Among the available synthesis techniques, ionizing-radiation-induced fabrication stands out as an environmentally friendly method for hydrogel preparation.