Severe traumatic injury is associated with profound changes in DNA methylation.

Whether DNA methylation changes follow human physical trauma is uncertain. We aimed to investigate if severe trauma was associated with DNA methylation changes. In a prospective, observational, clinical study, we included severely injured adults and adults undergoing elective surgery (controls).

Experiences of pain communication in endometriosis: A meta-synthesis.

Introduction: Endometriosis is the leading cause of chronic pelvic pain among women. The pain associated with endometriosis significantly impacts various aspects of patients' quality of life. A notable void in the literature is the absence of a systematic review exploring pain communication between patients with endometriosis and healthcare professionals.

Identification of streptomycin-resistant in Iowa.

Erwinia amylovora is a bacterial pathogen that causes fire blight, an important disease in apples and pears. Applying the antibiotic streptomycin during the phenological bloom stage is considered the most effective management tactic for fire blight. Though streptomycin-resistant (SmR) E.

Reliably calibrating X-ray images required for preoperative planning of THA using a device-adapted magnification factor.

Background And Aim: Calibrated pelvic X-ray images are needed in the preoperative planning of total hip arthroplasty (THA) to predict component sizes. Errors and mismatch in the size of one or more components are reported, which can lead to clinically relevant complications. Our aim is to investigate whether we can solve the fundamental problem of X-ray calibration and whether traditional X-ray still has a place in preoperative planning despite improved radiological alternatives.

Midlife sensory and motor functions improve prediction of blood-based measures of neurodegeneration and Alzheimer's disease in late middle-age.

Introduction: We assessed whether midlife sensory and motor functions added to prediction models using the Cardiovascular Risk Factors, Aging, and Incidence of Dementia Score (CAIDE) and Framingham Risk Score (FRS) improve risk predictions of 10-year changes in biomarkers of neurodegeneration and Alzheimer's disease.

Methods: Longitudinal data of  = 1529 (mean age 49years) Beaver Dam Offspring Study participants from baseline, 5-year, and 10-year follow-up were included. We tested whether including baseline sensory (hearing, vision, olfactory) impairment and motor function measures improves CAIDE or FRS risk predictions of 10-year incidence of biomarker positivity of serum-based neurofilament light chain (NfL) and amyloid beta (Aβ)/Aβ using logistic regression.