Publications by authors named "A Puliafito"
Article Synopsis
- Intraperitoneal cellular immunotherapy using CAR-redirected lymphocytes shows promise for tackling peritoneal carcinomatosis from ovarian cancer, currently under clinical trial evaluation.
- Researchers developed 3D experimental models that mimic the unique environment of peritoneal carcinomatosis, demonstrating that MSLN-CAR.CIK lymphocytes effectively kill ovarian cancer cells both in liquid and solid tumor contexts.
- The study revealed that fluid flow enhances tumor localization and killing in floating structures, while CAR-CIK cells are capable of penetrating and targeting solid tumor aggregates, providing insights for future locoregional cell therapy strategies in affected patients.
The breadth and depth at which cancer models are interrogated contribute to the successful clinical translation of drug discovery efforts. In colorectal cancer (CRC), model availability is limited by a dearth of large-scale collections of patient-derived xenografts (PDXs) and paired tumoroids from metastatic disease, where experimental therapies are typically tested. Here we introduce XENTURION, an open-science resource offering a platform of 128 PDX models from patients with metastatic CRC, along with matched PDX-derived tumoroids.
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- The vision of Cyber-Physical Systems leads to a new architectural design for Smart Environments, affecting how systems in Smart Cities are developed and implemented.
- Key components of this design include modular architecture, resource-sharing strategies, and specific deployment methods like microservices and Function as a Service (FaaS).
- The paper proposes a framework for Digital Decisioning, which merges human knowledge with data-driven insights (like machine learning) to improve decision-making and application development in Smart Cities.
Two-fluid dynamics and micron-thin boundary layers shape cytoplasmic flows in early embryos.
Proc Natl Acad Sci U S A
October 2023
Cytoplasmic flows are widely emerging as key functional players in development. In early embryos, flows drive the spreading of nuclei across the embryo. Here, we combine hydrodynamic modeling with quantitative imaging to develop a two-fluid model that features an active actomyosin gel and a passive viscous cytosol.
View Article and Find Full Text PDFThe Internet of Things (IoT) is transforming various domains, including smart energy management, by enabling the integration of complex digital and physical components in distributed cyber-physical systems (DCPSs). The design of DCPSs has so far been focused on performance-related, non-functional requirements. However, with the growing power consumption and computation expenses, sustainability is becoming an important aspect to consider.
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