Publications by authors named "A Puche"
Mitral/tufted cells (M/TCs) form complex local circuits with interneurons in the olfactory bulb and are powerfully inhibited by these interneurons. The horizontal limb of the diagonal band of Broca (HDB), the only GABAergic/inhibitory source of centrifugal circuit with the olfactory bulb, is known to target olfactory bulb interneurons, and we have shown targeting also to olfactory bulb glutamatergic neurons in vitro. However, the net efficacy of these circuits under different patterns of activation in vivo and the relative balance between the various targeted intact local and centrifugal circuits was the focus of this study.
View Article and Find Full Text PDFAims: Immune checkpoint inhibitors targeting programmed death-ligand 1 (PD-L1) have shown promising clinical outcomes in urothelial carcinoma (UC). The combined positive score (CPS) quantifies PD-L1 22C3 expression in UC, but it can vary between pathologists due to the consideration of both immune and tumour cell positivity.
Methods And Results: An artificial intelligence (AI)-powered PD-L1 CPS analyser was developed using 1,275,907 cells and 6175.
Article Synopsis
- * Researchers used a combination of advanced techniques, including CRISPR and phosphoproteomics, to study how neuroligin-3 localizes to different types of synapses in mouse and human brains.
- * Findings revealed that neuroligin-3 is region-specific, mainly found in excitatory synapses in the cortex and inhibitory synapses in subcortical areas, with its localization regulated by phosphorylation, affecting its interactions with other synaptic proteins.
Corrigendum to "Microvascular inflammation in the absence of human leukocyte antigen-donor-specific antibody and C4d: An orphan category in Banff classification with cytotoxic T and natural killer cell infiltration" [American Journal of Transplantation 23 (2023) 464-474].
Am J Transplant
April 2024
Article Synopsis
- Social interactions can help protect against substance use disorders, but how sensory experiences, like smell, influence this is not well understood.
- This study tested the olfactory system's role in rats by removing their olfactory bulbs and observing their social behaviors and drug cravings.
- Results indicated that rats with a functioning sense of smell preferred social interactions over cocaine, while those with impaired smell favored cocaine; using partner odors can help reduce cravings and promote abstinence.