Publications by authors named "A Pucciarelli"
Despite initial high response rates to first-line EGFR TKI, all non-small-cell lung cancer (NSCLC) with EGFR-activating mutation will ultimately develop resistance to treatment. Identification of resistance mechanisms is critical to adapt treatment and improve patient outcomes. Here, we show that a transcript that encodes full-length catalytic subunit 2B of calcineurin accumulates in EGFR-mutant NSCLC cells with acquired resistance against different EGFR TKIs and in post-progression biopsies of NSCLC patients treated with EGFR TKIs.
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- * Traditional diagnosis relies on bacterial isolation, which is slow, while Polymerase Chain Reaction (PCR) offers a faster and more sensitive alternative.
- * The study developed a droplet digital PCR (ddPCR) protocol for detecting Brucella in buffalo tissue samples, showing high sensitivity and accuracy, making it a promising tool for veterinary diagnostics.
Article Synopsis
- The study examined 91 exotic companion mammals from pet shops in southern Italy for the presence of eight potential zoonotic viruses using advanced PCR techniques.
- Only one rat tested positive for aichivirus, which showed a close genetic relationship to a strain identified in China, indicating possible introduction from Asia.
- Continuous monitoring of these animals is essential to prevent the spread of pathogens to humans and domestic animals, emphasizing the need for further research on zoonotic viruses.
Over the last few decades, endovascular revascularization techniques have revolutionized the treatment of peripheral artery disease, offering a less invasive alternative to surgery. However, the successful treatment of heavily calcified lesions is often compromised by various vascular complications, including recoils, dissections, and the need for target vessel reinterventions. This has prompted the development of several tools for lesion preparation, with the aim of achieving better procedural outcomes.
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