Genotoxic effect of tocolytic drug ritodrine in combination with smoking during pregnancy.

Objective: Tocolytic drugs are used widely in order to prevent preterm birth. Ritodrine, is the only food and drug administration (FDA) approved drug for tocolytic use. We estimated the cytogenetic effect of ritodrine administered as maternal therapy, alone or in combination with smoking, in women and their neonates.

The relationship between Anti-Müllerian hormone and other reproductive parameters in normal women and in women with polycystic ovary syndrome.

Objective: To correlate Anti-Müllerian hormone (AMH) levels with years since menarche as well as to investigate the AMH relationship with ovarian morphology and levels of androgens in healthy normo- ovulatory women and in women with polycystic ovary syndrome (PCOS).

Design: Prospective clinical study.

Setting: University Hospital of Alexandroupolis, Lito Maternity Hospital.

Effect of maternal smoking during pregnancy on fetus: a cytogenetic perspective.

Objective: The examination of the genotoxic, cytostatic and cytotoxic effects of smoking during pregnancy.

Method: Lymphocyte cultures of peripheral blood were received from 20 women who smoked during pregnancy as well as umbilical cord blood of their newborns. Fluorescence Plus Giemsa staining technique was used in order to perform cytogenetic analyses for three indices, Sister Chromatid Exchanges (SCEs), Proliferation Rate Index (PRI) and Mitotic Index (MI).

Cytogenetic evaluation of pre-pregnancy smoking in maternal and newborn lymphocytes.

Objective: To study cytogenetic damage in order to estimate the effect of pre-pregnancy smoking on pregnant women and their foetuses.

Study Design: Lymphocyte cultures were obtained from peripheral blood of 20 women who quit smoking during pregnancy, and umbilical cord blood of their newborns at delivery. Cytogenetic analyses were performed for sister chromatid exchanges (SCEs), proliferation rate index (PRI) and mitotic index (MI) using the Fluorescence Plus Giemsa staining technique.

Conservative surgery for borderline ovarian tumors--emphasis on fertility preservation. A review.

Background: Borderline ovarian tumors account for 15-20% of all ovarian epithelial tumors. Since their original description in 1929, our knowledge of their natural history and molecular pathology has advanced most dramatically over the last two decades. This improved knowledge of BOT has permitted to drastically decrease the therapeutics of these tumors, which remains mostly surgical.