A real-world, non-interventional, prospective study of the effectiveness and safety of apremilast in bio-naïve adults with moderate plaque psoriasis treated in the routine care in Greece - the 'APRAISAL' study.

Background: Real-world data in patients with moderate psoriasis treated with apremilast is limited.

Objectives: To evaluate the effectiveness and safety of apremilast in bio-naïve patients with moderate psoriasis in real-world clinical settings.

Methods: This was a 52-week multicenter, observational, prospective study of adult outpatients with moderate psoriasis {[10% < body surface area < 20% or 10 < psoriasis area severity index (PASI) < 20] and 10 < dermatology quality of life index (DLQI) < 20} initiated on apremilast ≤7 days before enrollment.

Valorization and Mechanical Recycling of Heterogeneous Post-Consumer Polymer Waste through a Mechano-Chemical Process.

In this paper, a sustainable strategy to valorize and recycle heterogeneous polymer-based post-consumer waste is proposed. This strategy is based on a high-energy mechano-chemical treatment and has been applied to a polyolefin-rich fraction, coded as FIL/S, deriving from household plastic waste collection. This processing, performed in a planetary ball mill, allowed us to obtain fine grinding and, consequently, to induce an intimate mixing of the different polymer fractions and contaminants composing the FIL/S, as demonstrated by SEM analysis.

Nanosilicates in Compatibilized Mixed Recycled Polyolefins: Rheological Behavior and Film Production in a Circular Approach.

Currently, plastic packaging represents a global challenge and has become a key point of attention for governments, media and consumers due to the visibility of the waste it generates. Despite their high resource efficiency, the perceived non-recyclability of polymeric films risks precluding them from being a relevant packaging solution in a circular economy approach. In this regard, the aim of this study was to implement a strategy to try closing the loop, via the mechanical recycling of post-consumer flexible packaging of small size (denoted as Fil-s) to obtain new films.

Effectiveness and safety of apremilast in biologic-naïve patients with moderate psoriasis treated in routine clinical practice in Greece: the APRAISAL study.

Background: Apremilast is an oral phosphodiesterase-4 inhibitor indicated for patients with moderate-to-severe chronic plaque psoriasis and active psoriatic arthritis.

Objectives: To examine the effectiveness of apremilast on Dermatology Life Quality Index (DLQI), Psoriasis Area and Severity Index (PASI) and nail, scalp and palmoplantar involvement, when administered prior to biologics.

Methods: This 52-week real-world study included biologic-naive adults with moderate psoriasis (psoriasis-involved body surface area 10% to <20%, or PASI 10 to <20 and DLQI 10 to <20).

Study on Improving the Processability and Properties of Mixed Polyolefin Post-Consumer Plastics for Piping Applications.

This study focuses on the upgrading strategies to make Fil-s (acronym for film-small), a polyolefin-based material coming from the mechanical recycling of post-consumer flexible packaging, fit for re-use in the piping sector. The effects of washing treatments (at cold and hot conditions) and the addition of an experimental compatibilizer on the chemical-physical properties of Fil-s were first assessed. The measurements of some key properties (density, melt flow index, flexural modulus, yield strength), for both Fil-s as such and the different developed Fil-s based systems, was also conducted in order to evaluate the suitability of this complex and challenging waste stream to replace virgin PE-based pipe and fitting products, in compliance to ASTM D3350 standard.