Publications by authors named "A Priyanka"
Article Synopsis
- * A study in Bangladesh compared urban and rural populations, finding that 70.6% of urban participants were vitamin D deficient, compared to only 32% in rural areas, despite similar sun exposure.
- * The study emphasizes the necessity for more extensive research to understand the causes of vitamin D deficiencies in Bangladesh and the differences in levels between urban and rural populations.
Importance: Schizophrenia is associated with increased age-related morbidity, mortality, and frailty, which are not entirely explained by behavioral factors. Prior studies using epigenetic clocks have suggested that schizophrenia is associated with accelerated aging, however these studies have primarily used unidimensional clocks that summarize aging as a single "biological age" score.
Objective: This meta-analysis uses multidimensional epigenetic clocks that split aging into multiple scores to analyze biological aging in schizophrenia.
Article Synopsis
- Aging biomarkers can help researchers quickly assess the effects of aging interventions, bypassing the need for long-term studies, but their effectiveness as surrogate endpoints needs validation.
- Epigenetic clocks, which are developed from DNA methylation patterns, show promise in this area and are being investigated for their responsiveness to various aging interventions.
- The TranslAGE-Response database compiles data from numerous studies to identify patterns in how different interventions affect epigenetic clocks, revealing that some interventions have consistent effects while others do not, and highlighting the importance of considering study population and duration in these assessments.
In a modern haematology laboratory, the complete and differential counts of blood are performed using complex haematology auto analyzers. In order to ensure the accuracy and reliability of test results, various regulatory authorities have prescribed the use of stabilized blood controls. The major pitfalls of these blood controls are their short shelf life.
View Article and Find Full Text PDFThe ubiquitin-specific protease (USP) family of deubiquitinases (DUBs) controls cellular ubiquitin-dependent signaling events. This generates therapeutic potential, with active-site inhibitors in preclinical and clinical studies. Understanding of the USP active site is primarily guided by USP7 data, where the catalytic triad consists of cysteine, histidine, and a third residue (third critical residue), which polarizes the histidine through a hydrogen bond.
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