Comparison of the Level of DNA-Hydrolyzing Polyclonal IgG Antibodies in Sera of Patients with Hashimoto's Thyroiditis and Nontoxic Nodal Goiter.

Various catalytically active IgG antibodies or abzymes have been recently detected in the sera of patients with several autoimmune pathologies, where their presence is most probably associated with autoimmunization. Here we show for the first time that IgG from peripheral blood of patients with Hashimoto's thyroiditis and nontoxic nodal goiter possesses DNase activity. The properties of the DNase IgGs distinguished them from other known human DNases.

Effect of different drugs on the level of DNA-hydrolyzing polyclonal IgG antibodies in sera of patients with Hashimoto's thyroiditis and nontoxic nodal goiter.

Background: DNA-hydrolyzing IgG antibodies have been detected recently in the sera of patients with several autoimmune diseases.

Material And Methods: The relative activity of DNA-hydrolyzing IgG from the sera of patients with Hashimoto's thyroiditis and with non-toxic nodal goiter as a function of the patient's condition were measured. The effect of different drugs on the level of DNA-hydrolyzing IgG, functional activity of thyroid gland, and improvement of clinical condition of two groups of patients were analyzed.

Occult bacteremia and septicemia in the febrile child younger than two years.

The literature on the assessment and the preferred treatment strategies for children without a focus of infection is reviewed. Opinions are offered regarding the diagnostic evaluation and therapeutic interventions for febrile infants and children who are at risk for occult bacteremia or sepsis. Clinicians are encouraged to consider the proposed strategies but not to supplant their prevailing practice.