Publications by authors named "A Primerano"
Skin microbiota plays an essential role in the development and function of the cutaneous immune system, in the maintenance of the skin barrier through the release of antimicrobial peptides, and in the metabolism of some natural products. With the aim of characterizing changes in the cutaneous microbiota specifically associated with wound healing in the diabetic condition, we performed a 16 S rRNA gene Next Generation Sequencing of skin swabs taken within the ulcer bed of ten diabetic patients before (t0) and after 20 days of therapy (t20) with a fluorescein-based galenic treatment. Considering the twenty most representative genera, we found at t20 an increase of Corynebacterium, Peptostreptococcus, and Streptococcus, and a decrease of Enterococcus, Finegoldia, and Peptoniphilus genera.
View Article and Find Full Text PDFObjective: Many but not all persons with bipolar disorder require hospital care because of severe mood episodes. Likewise, some but not all patients experience long-term occupational dysfunction that extends beyond acute mood episodes. It is not known whether these dissimilar outcomes of bipolar disorder are driven by different polygenic profiles.
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- * The study aimed to examine histone acetylation in RDEB skin and to evaluate the potential of histone deacetylase inhibitors (HDACi) like givinostat and valproic acid (VPA) as treatments to reduce fibrosis and disease advancement in RDEB models.
- * Findings indicated that decreased histone acetylation is present in RDEB skin, and treating RDEB fibroblasts with HDACi reduced fibrotic behavior; VPA treatment in RDEB mice improved symptoms related to
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- Nesfatin-1 is a neuropeptide that plays a role in controlling hunger, eating, and mood disorders, and this study explored its secretion in both animal and human fat cells.
- The research found that nesfatin-1 levels were significantly higher in fat cells exposed to low oxygen (hypoxic conditions) and in the visceral fat of obese individuals compared to normal-weight subjects.
- There were no significant differences in nesfatin-1 levels based on BMI or eating disorder diagnosis, but specific genetic polymorphisms were linked to higher levels and correlations with various eating behaviors were identified, suggesting nesfatin-1 could be a useful biomarker for eating disorders in obese patients.
Autoimmune response to cutaneous basement membrane components superimposed on a genetic skin fragility disease, hereditary epidermolysis bullosa (EB), has been described, but its effects on disease course remain unclear. We report a 69-year-old individual with congenital skin fragility and acral trauma-induced blistering that had suddenly worsened with the onset of severe itch and diffuse spontaneous inflammatory blisters. Next-generation sequencing identified compound heterozygous null and missense mutations, allowing the diagnosis of recessive dystrophic EB.
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