Anti-Pythium insidiosum activity of three novel triazole compounds: synthesis, pharmacokinetic and toxicological parameters.

Pythiosis, caused by Pythium insidiosum, is an infectious and non-transmissible disease affecting horses, dogs, and humans, with no effective drug treatment available. Triazoles are compounds of interest for their potential pharmacological properties against fungi and bacteria. In this study, we synthesized three new triazole compounds (C1, C2, and C3) to assess their in vitro activities against P.

Nicotine and Vape: Drugs of the Same Profile Flock Together.

Smoking, a major behavioral health burden, causes preventable and premature deaths globally. Nicotine, the addictive component present in tobacco products and Electronic cigarettes (E-cigarettes, vape), can bind to nicotinic acetylcholine receptors in the brain to trigger a dopamine release that reinforces smoking. Despite the widespread usage of nicotine, its mechanisms of toxicity, particularly in e-cigarettes, are poorly understood.

Marine algal (seaweed) flora of Faial Island, Azores.

Background: A comprehensive checklist of the marine flora from Faial Island, mid-north Atlantic, is still unavailable, despite the numerous works that gathered data around its coasts for over 150 years. This study brings together and harmonises all macroalgae collections and taxonomical records from multiple projects and teams over the last thirty years.The result is a list of taxonomic records and georeferenced species occurrence data that substantially increases our knowledge of the coastal Azorean marine biodiversity while providing key information for future ecological studies and to support local, marine management and conservation.

Evaluation and economic analysis of fermented fish viscera silage in diets for tambaqui (Colossoma macropomum) and its effects on the physical quality of pellets, growth performance, health parameters.

The production of silage using fish viscera can be carried out with straightforward methods and permits the exploitation of nutrients that are usually discarded. This process fosters the concept of circular aquaculture. The aim of this study was to evaluate the inclusion of increasing levels of fish viscera silage (VS) on the physical quality of the feed pellets and their effects on their growth performance, health parameters and on economic indices when the experimental extruded feed was offered to tambaqui.