Publications by authors named "A Prasse"
Background: Interstitial lung disease (ILD) is rarer in children (chILD) than adults, but with increasing diagnostic awareness, more cases are being discovered. chILD prognosis is often poor, but increasing numbers are now surviving into adulthood.
Aim: To characterize chILD-survivors and identify their impact on adult-ILD centers.
Rationale: The association between immune-cell-specific transcriptomic profiles and Idiopathic Pulmonary Fibrosis (IPF) mortality is unknown.
Objectives: To determine immune-cell-specific transcriptomic profiles associated with IPF mortality.
Methods: We profiled peripheral blood mononuclear cells (PBMC) in 18 participants [University of South Florida: IPF, COVID-19, post-COVID-19 Interstitial Lung Disease (Post-COVID-19 ILD), controls] by single-cell RNA sequencing (scRNA-seq) and identified 16 immune-cell-specific transcriptomic profiles.
Single-Cell Analysis Reveals Novel Immune Perturbations in Fibrotic Hypersensitivity Pneumonitis.
Am J Respir Crit Care Med
November 2024
Article Synopsis
- Fibrotic hypersensitivity pneumonitis (FHP) is an interstitial lung disease linked to unclear immune reactions, and researchers studied immune cells from various patient groups using single-cell RNA sequencing.
- The analysis revealed an increase in specific immune cells, including classical monocytes and GZM cytotoxic T cells, in FHP patients compared to controls and those with idiopathic pulmonary fibrosis (IPF).
- These findings highlight unique immune disturbances in FHP, suggesting potential new biomarkers and treatment strategies based on the distinct inflammatory responses observed in the disease.
The present recommendations on the therapy of sarcoidosis of the German Respiratory Society (DGP) was written in 2023 as a German-language supplement and update of the international guidelines of the European Respiratory Society (ERS) from 2021. It contains 5 PICO questions (Patients, Intervention, Comparison, Outcomes) agreed in the consensus process, which are explained in the background text of the four articles: Confirmation of diagnosis and monitoring of the disease under therapy, general therapy recommendations, therapy of cutaneous sarcoidosis, therapy of cardiac sarcoidosis.
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