Creating building-level, three-dimensional digital models of historic urban neighborhoods from Sanborn Fire Insurance maps using machine learning.

Sanborn Fire Insurance maps contain a wealth of building-level information about U.S. cities dating back to the late 19th century.

Realizable accessibility: evaluating the reliability of public transit accessibility using high-resolution real-time data.

The widespread availability of high spatial and temporal resolution public transit data is improving the measurement and analysis of public transit-based accessibility to crucial community resources such as jobs and health care. A common approach is leveraging transit route and schedule data published by transit agencies. However, this often results in accessibility overestimations due to endemic delays due to traffic and incidents in bus systems.

311 service requests as indicators of neighborhood distress and opioid use disorder.

Opioid use disorder and overdose deaths is a public health crisis in the United States, and there is increasing recognition that its etiology is rooted in part by social determinants such as poverty, isolation and social upheaval. Limiting research and policy interventions is the low temporal and spatial resolution of publicly available administrative data such as census data. We explore the use of municipal service requests (also known as "311" requests) as high resolution spatial and temporal indicators of neighborhood social distress and opioid misuse.

Galectin-8 binds to the Farnesylated C-terminus of K-Ras4B and Modifies Ras/ERK Signaling and Migration in Pancreatic and Lung Carcinoma Cells.

K-Ras is the most prominent driver of oncogenesis and no effective K-Ras inhibitors have been established despite decades of intensive research. Identifying new K-Ras-binding proteins and their interaction domains offers the opportunity for defining new approaches in tackling oncogenic K-Ras. We have identified Galectin-8 as a novel, direct binding protein for K-Ras4B by mass spectrometry analyses and protein interaction studies.

Lhermitte-Duclos disease (Dysplastic gangliocytoma of the cerebellum).

Objective: Dysplastic gangliocytoma of the cerebellum (Lhermitte-Duclos disease) is a rare hamartomatous lesion of the cerebellar cortex. The pathogenesis of the disease is still poorly understood. Lhermitte-Duclos disease was recently considered to be part of a multiple hamartoma-neoplasia syndrome (Cowden disease).