Publications by authors named "A Porcu"
Primary pelvic peritoneal masses, not arising from major organs, are uncommon in adults. Leiomyomas are a group of benign smooth muscle tumors, most commonly found in the uterus in premenopausal women (70-80%). Extra-uterine locations are very rare and more frequent in women.
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- Pancreatic ductal adenocarcinoma (PDAC) is difficult to diagnose early due to vague symptoms and a lack of biomarkers, and the study aims to explore the role of microRNAs (miRNAs) in PDAC progression and cancer stem cells (CSCs).
- Researchers analyzed miRNA profiles from PDAC patient samples and cell lines to identify specific miRNAs associated with the disease and examined their expression in CSC models.
- The study identified a panel of 9 PDAC-associated miRNAs, showing significant dysregulation particularly in CSC models, with notable overexpression of miR-4486, miR-216a-5p, and miR-216b-5p in cancer stem cells compared to
The advent of artificial lighting, particularly during the evening and night, has significantly altered the predictable daily light and dark cycles in recent times. Altered light environments disrupt the biological clock and negatively impact mood and cognition. Although adolescents commonly experience chronic changes in light/dark cycles, our understanding of how the adolescents' brain adapts to altered light environments remains limited.
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- The study looked at how diabetes affects patients with pancreatic cancer who had surgery to remove part of their pancreas.
- They found that having diabetes didn't change the chances of surviving for five years or the chances of cancer coming back after surgery.
- So, doctors can treat diabetic patients the same as those without diabetes when considering surgery.
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- Patients undergoing pancreaticoduodenectomy for distal cholangiocarcinoma (dCCA) have a high recurrence rate, with 65% developing recurrence mostly within three years post-surgery.
- The study identified common recurrence patterns, including local, distant, and mixed types, with primary sites being the pancreatic bed, liver, and lungs.
- Key predictive factors for recurrence included cancer stage, type of surgical resection, and various histological features, helping inform potential follow-up treatments or strategies.