Nanohyperthermia of malignant tumors. II. In vivo tumor heating with manganese perovskite nanoparticles.

Objectives: To evaluate the ability of manganese perovskite nanoparticles (lanthanum-strontium manganite) to heat the tumor tissue in vivo under action of external alternating magnetic field.

Materials And Methods: The magnetic fluid on the basis of nanoparticles of perovskite manganite was tested in the heating experiments using of alternating magnetic field of frequency 300 kHz and amplitude 7.7 kA/m.

Nanohyperthermia of malignant tumors. I. Lanthanum-strontium manganite magnetic fluid as potential inducer of tumor hyperthermia.

Objectives: To synthesize magnetic particles of lanthanum-strontium manganite, prepare the magnetic fluid (MF), evaluate the generation of heat by particles and determine their common toxiсity.

Methods: Nanoparticles based on the solid solutions of lanthanum-strontium manganite (La(1-x)Sr(x)MnO(3)) have been synthesized by a sol-gel method. Conventional methods of experimental oncology were used.

[Morphofunctional analysis of structural elements of the cornea after exposure to CO2 laser].

In the dynamics of a chronic experiment and after it, the state of the cornea and blood circulation in the uveal tract were investigated, along with the morphological studies of the occipital areas of the brain (area 17) and calculations of the thermal processes in the cornea tissues. Results of the complex studies confirmed that opacification of the cornea was not induced by the damaging heat effect of the CO2-laser irradiation with the energy of illumination at 4.2 x 10(-2) Wt.