Publications by authors named "A Pluzanski"
Article Synopsis
- * A pooled analysis of clinical trials showed that patients receiving this combination treatment had better overall survival (17.4 months) compared to those receiving chemotherapy alone (11.3 months) at a median follow-up of 73.7 months.
- * The combination treatment also resulted in higher progression-free survival and objective response rates without new safety concerns, making it a promising first-line option for hard-to-treat NSCLC cases.
We investigated association between skin adverse events (AEs) and efficacy with dacomitinib in patients with -positive non-small-cell lung cancer (NSCLC). analyses from ARCHER 1050 evaluated efficacy in patients who did and did not experience grade ≥2 skin AEs with dacomitinib. Landmark analyses were performed at 3 and 6 months.
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- Many patients with advanced cancer, like tracheal cancers, can't be cured, making palliative care vital.
- Existing studies mostly look at palliative care as part of broader cancer treatments and don't focus solely on tracheal tumors.
- This review presents the first detailed clinical guidelines for palliative treatment specifically for tracheal cancer, addressing unique challenges not covered by other cancer treatment guidelines.
Article Synopsis
- A retrospective study assessed the effectiveness of crizotinib versus newer ROS1-targeted therapies in patients with advanced non-small-cell lung cancer (NSCLC).
- Among 49 ROS1-expressing patients, those treated with newer agents like entrectinib and repotrectinib had higher response and disease control rates compared to those treated with crizotinib.
- Despite crizotinib showing comparable results, the newer therapies demonstrated longer median progression-free survival, highlighting the potential benefits of newer treatment options.
Pulmonary benign metastasizing leiomyoma (PBML) is a rare condition characterized by the spread of uterine leiomyomas to the lungs, typically observed in premenopausal women with a history of hysterectomy or myomectomy. This report presents a unique case of a postmenopausal woman, aged 65, that emphasizes the clinical, radiological, histologic, and immunohistochemical aspects of the disease. On presentation, the patient suffered from severe pain.
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