Publications by authors named "A Plawski"
Adenosine deaminase acting on RNA 1 (ADAR1) plays an essential role in the development of malignancies by modifying the expression of different oncogenes. ADAR1 presents three distinct activities: adenosine-to-inosine RNA editing, modulating IFN pathways, and response to cellular stress factors. Following stressors such as heat shock, ADAR1p110 isoform relocates from the nucleus to the cytoplasm, where it suppresses RNA degradation which leads to the arrest of apoptosis and cell survival.
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- Colorectal cancer (CRC) is a common and deadly cancer type with varied prevalence across different populations, with most cases lacking clear genetic causes.
- The research on genetic factors associated with low risk for CRC has produced inconsistent results, leading to confusion in the field, prompting the authors to consolidate existing knowledge and identify specific genetic markers related to cancer risk.
- There's a call for large-scale testing of low-penetrance genetic variants, emphasizing the need for collaboration among various stakeholders, including healthcare professionals and policymakers, to prioritize CRC research despite potential costs.
Background: Development of sequential changes of mucous leading to gastric cancer and familial cases of gastric cancer of intestinal type is widely connected with Helicobacter pylori infections. In this study we analysed variants of genes involved in cancerogenesis and inflammatory processes of intestines in patients infected with H.pylori.
View Article and Find Full Text PDFPrevious studies have demonstrated an association of the NC_000012.12:g.53962605A > G, (rs2366152) single-nucleotide variant (SNV) situated in the long noncoding homeobox transcript antisense intergenic RNA (HOTAIR) gene with HPV16-related cervical cancer pathogenesis.
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