Publications by authors named "A Pitino"
Randomized clinical trials (RCTs) are pivotal in medical research, offering critical evidence on the efficacy and safety of treatments. This paper explores the distinct purposes and designs of superiority, non-inferiority, equivalence, and pragmatic trials, each addressing unique research questions. Superiority trials aim to demonstrate a new treatment's effectiveness over existing standards, while non-inferiority and equivalence trials focus on ensuring new treatments are not significantly worse or are similar to existing ones, respectively.
View Article and Find Full Text PDFUnlabelled: A retrospective analysis was performed to evaluate the frequency of vitamin D blood testing in individuals from the Padua province, Veneto, Italy from 2005 to 2016. A significant increase in the frequency of vitamin D blood tests, particularly in females was observed and in individuals with severe vitamin D deficiency (Class I).
Purpose: Vitamin D deficiency has been linked to negative health outcomes that extend beyond bone-related conditions.
Article Synopsis
- This study examined the effects of D-VTd induction therapy on recovery after autologous stem cell transplantation in patients with newly diagnosed multiple myeloma (NDMM).
- Sixty patients received D-VTd while 80 others received VTd as a control, with results showing that D-VTd led to a slightly longer time for neutrophil and platelet recovery.
- Despite delayed engraftment in the D-VTd group and a higher incidence of febrile neutropenia, the study concluded that D-VTd does not negatively affect overall transplant safety outcomes.
Hypercontractile phenotype (HP) of the left ventricle (LV) is an actionable therapeutic target in patients with chronic coronary syndromes (CCS) or heart failure (HF), but its clinical recognition remains difficult. To assess the clinical variables associated with the HP. In a prospective, observational, multicenter study, we recruited 5122 patients (age 65 ± 11 years, 2974 males, 58%) with CCS and/or HF with preserved ejection fraction (EF).
View Article and Find Full Text PDFArticle Synopsis
- Atrial fibrillation (AF) in older patients is linked to cognitive decline and dementia, with ongoing debate about the benefits of anticoagulants on cognitive function.
- This study involved 983 older patients comparing the cognitive decline between those on non-vitamin K oral anticoagulants (NOACs) and vitamin K antagonists (VKAs) using the Mini Mental State Examination (MMSE) score over an average of 7.2 years.
- Results showed that patients on NOACs had a significantly lesser decline in cognitive function compared to VKAs, indicating that NOACs may be more beneficial for preserving cognitive health in older AF patients despite their higher age and comorbidities.