Publications by authors named "A Pisanu"
Background: Recent studies suggest that low-molecular-weight heparin (LMWH) may play a role in mitigating the severity of acute pancreatitis (AP). This systematic review and meta-analysis aims to synthesise existing evidence on the effectiveness and safety of LMWH in the treatment of moderately-severe and severe AP.
Methods: This systematic review and meta-analysis was conducted in accordance with the 2020 update of the PRISMA guidelines and the Cochrane Handbook for Systematic Reviews of Interventions.
Background: There is lack of data on the association between socioeconomic factors, guidelines compliance and clinical outcomes among patients with acute biliary pancreatitis (ABP).
Methods: Post-hoc analysis of the international MANCTRA-1 registry evaluating the impact of regional disparities as indicated by the Human Development Index (HDI), and guideline compliance on ABP clinical outcomes. Multivariable logistic regression models were employed to identify prognostic factors associated with mortality and readmission.
A machine learning predictive model for recurrence of resected distal cholangiocarcinoma: Development and validation of predictive model using artificial intelligence.
Eur J Surg Oncol
July 2024
Introduction: Distal Cholangiocarcinoma (dCCA) represents a challenge in hepatobiliary oncology, that requires nuanced post-resection prognostic modeling. Conventional staging criteria may oversimplify dCCA complexities, prompting the exploration of novel prognostic factors and methodologies, including machine learning algorithms. This study aims to develop a machine learning predictive model for recurrence after resected dCCA.
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- The study surveyed general surgeons from April to May 2023 to understand their workload, academic involvement, and rest after on-call duty, receiving 1,046 responses with diverse representation, particularly from Europe and North America.
- Over 78% of respondents engaged in research activities, with European surgeons averaging more published studies yearly, while teaching participation was highest in North America and Africa.
- Results indicated significant disparities in on-call frequencies and post-shift days off, with only 35.1% of surgeons receiving a day off afterwards, influenced by factors like Human Development Index (HDI) and hospital capacity.
Article Synopsis
- The study aimed to identify risk factors linked to the failure of non-operative treatment in patients with certain types of diverticular abscesses, using a multicentre case-control approach.
- Among the 116 patients who experienced treatment failure (27.04%), significant predictors included the Hinchey classification IIb, smoking, and the presence of air bubbles within the abscess.
- The findings highlight the effectiveness of non-operative treatments but suggest that young smokers with IIb Hinchey diverticulitis need closer monitoring and that further research should focus on the role of image-guided drainage.