Publications by authors named "A Pinson"
(Cb), the causative agent of Q fever, replicates within host macrophages by modulating immune responses through poorly understood mechanisms. Long non-coding RNAs (lncRNAs) are emerging as critical regulators of inflammation, yet their role in Cb pathogenesis remains largely unexplored. Here, we employed a global transcriptomic approach to identify lncRNAs specific to Cb infection in THP-1 derived macrophages, compared to 15 other microbial infections.
View Article and Find Full Text PDFBackground: Venous thromboembolism (VTE) is a leading cause of preventable mortality among hospitalized patients, but appropriate risk assessment and thromboprophylaxis remain underutilized or misapplied.
Objectives: We conducted an electronic survey of US health care providers to explore attitudes, practices, and barriers related to thromboprophylaxis in adult hospitalized patients and at discharge.
Results: A total of 607 US respondents completed the survey: 63.
Article Synopsis
- The study examined whether having low platelet counts (thrombocytopenia) increases the risk of bleeding in patients with atrial fibrillation (AF) on anticoagulants, comparing two groups: those with low platelets (<100,000/μL) and those with normal counts (>150,000/μL).
- Results showed that patients with AF and thrombocytopenia had significantly higher rates of major bleeding (13.3% vs 5.7%) and clinically relevant bleeding (24.5% vs 16.7%) after one year.
- Thrombocytopenia was confirmed as an independent risk factor for major bleeding, with the risk increasing as the severity of low platelet counts worsened, highlighting
Herai . discuss the known fact that a low percentage of modern humans who lack any overt phenotypes carry the ancestral allele. Our paper demonstrates that the amino acid substitution in TKTL1 increases neural progenitor cells and neurogenesis in the developing brain.
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