Cytotoxic Activity of Saponins and Sapogenins Isolated from Willd. in Cancer Cell Lines.

The cytotoxic properties of two extracts from Willd. and three synthetic sapogenins were evaluated in different cancer cell lines (A549, SH-SY5Y, HepG2, and HeLa) to investigate their cytotoxic effects and determine if these cell lines activate the caspase pathway for apoptosis in response to saponin and sapogenin treatment. The saponin extracts were isolated from the agro-industrial waste of Willd.

Diagnosis of Alzheimer's Disease in Developed and Developing Countries: Systematic Review and Meta-Analysis of Diagnostic Test Accuracy.

Background: The present systematic review and meta-analysis of diagnostic test accuracy summarizes the last three decades in advances on diagnosis of Alzheimer's disease (AD) in developed and developing countries.

Objective: To determine the accuracy of biomarkers in diagnostic tools in AD, for example, cerebrospinal fluid, positron emission tomography (PET), and magnetic resonance imaging (MRI), etc.

Methods: The authors searched PubMed for published studies from 1990 to April 2020 on AD diagnostic biomarkers.

Curcumin-Celecoxib: a synergistic and rationale combination chemotherapy for breast cancer.

Objective: Over-expression of COX-2 has been linked with various molecular signaling such as carcinogenesis, invasiveness, and malignant tumour metastasis. Besides, the use of celecoxib is also related to lowering the risk of breast cancer. This study therefore designed to explore the synergistic inhibitory effect of the combination of curcumin and celecoxib on the growth of human breast cancer cells.

Effects of Extract on Triple-Negative Breast Cancer Cells Mediated Through EGFR Signaling.

Purpose: To evaluate the antiproliferative activity and the mechanisms of action of ethyl acetate (AMEA) extract and one of its active fractions on BT-20 TNBC cells.

Methods: The triple-negative human breast cancer BT-20 cells were used. After the preparation and extraction of ethyl acetate (AMEA), the ethyl acetate extract was exposed to a preparative thin layer chromatography (TLC) plate.

Inhibition of PAR-1 Receptor Signaling by Enoxaparin Reduces Cell Proliferation and Migration in A549 Cells.

Background/aim: Low-molecular weight heparins (LMWHs) may possess putative antitumoral properties; however, the underlying mechanism(s) remains elusive. We evaluated the antiproliferative and antimigratory effects of enoxaparin (a LMWH) in lung adenocarcinoma A549 cells, and assessed the possible mechanism involved, and the effect on doxorubicin's efficacy.

Materials And Methods: Proliferation and migration were evaluated using BrdU and transwell assays, respectively.