Publications by authors named "A Pinhasov"
Article Synopsis
- The opioid crisis has evolved into a global issue affecting various socioeconomic and cultural areas, with traditional treatment methods proving insufficient.
- A narrative review was conducted using multiple databases to explore the complex factors contributing to this epidemic, acknowledging the potential for bias in article selection.
- Despite some progress with Opioid Substitution Therapy, U.S. overdose deaths remain alarmingly high and are projected to increase; the authors suggest a need for a new treatment approach that targets brain neurotransmitter systems for better management.
Article Synopsis
- Borderline personality disorder (BPD) and post-traumatic stress disorder (PTSD) share similar neurobiological features, suggesting that BPD might be better classified as "traumatic personality stress disorder" (TPSD).
- The study explores how psychedelic-assisted therapy (PAT) could effectively treat both BPD and PTSD, emphasizing its role in stabilizing reward functions.
- Reclassifying BPD as TPSD may lead to more personalized treatment approaches, reduce stigma, and improve understanding and management of related psychological conditions.
Clonidine operates through agonism at the alpha-2A receptor, a specific subtype of the alpha-2-adrenergic receptor located predominantly in the prefrontal cortex. By inhibiting the release of norepinephrine, which is responsible for withdrawal symptoms, clonidine effectively addresses withdrawal-related conditions such as anxiety, hypertension, and tachycardia. The groundbreaking work by Gold .
View Article and Find Full Text PDFExercise promotes health and wellness, including its operation as a protective factor against a variety of psychological, neurological, and chronic diseases. Selenium and its biomarker, selenoprotein P (SEPP1), have been implicated in health, including cancer prevention, neurological function, and dopamine signaling. SEPP1 blood serum levels were compared with a one-way ANOVA between sedentary (SED), moderately exercised (MOD) [10 m/min starting at 10 min, increasing to 60 min], and high-intensity interval training (HIIT) exercised rats [30 min in intervals of 2-min followed by a 1-min break, speed progressively increased from 10 to 21 m/min].
View Article and Find Full Text PDFBackground: The exact mechanisms linking the gut microbiota and social behavior are still under investigation. We aimed to explore the role of the gut microbiota in shaping social behavior deficits using selectively bred mice possessing dominant (Dom) or submissive (Sub) behavior features. Sub mice exhibit asocial, depressive- and anxiety-like behaviors, as well as systemic inflammation, all of which are shaped by their impaired gut microbiota composition.
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