Publications by authors named "A Pietras"
Glioblastoma presents a formidable clinical challenge because of its complex microenvironment. Here, we characterized tumor-associated foam cells (TAFs), a type of lipid droplet-loaded macrophage, in human glioblastoma. Through extensive analyses of patient tumors, together with in vitro and in vivo investigations, we found that TAFs exhibit distinct protumorigenic characteristics related to hypoxia, mesenchymal transition, angiogenesis, and impaired phagocytosis, and their presence correlates with worse outcomes for patients with glioma.
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- * This study found that complement factor H (FH) acts as an ICOS ligand, enhancing Treg survival and function while increasing TGF-beta and IL-10 secretion, which suppresses T-cell activity.
- * Analysis in mouse models and patient data revealed that higher FH levels are linked to more Tregs and poorer patient outcomes, indicating that targeting FH could improve glioma treatment and prognosis.
Glioblastoma (GBM) is the most aggressive form of glioma with a high rate of relapse despite intensive treatment. Tumor recurrence is tightly linked to radio-resistance, which in turn is associated with hypoxia. Here, we discovered a strong link between hypoxia and local complement signaling using publicly available bulk, single-cell, and spatially resolved transcriptomic data from patients with GBM.
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- A novel dual-speed friction stir welding (FSW) tool was used to weld cast magnesium AZ91 and wrought aluminum 6082-T6, allowing for separate control of shoulder and pin rotation speeds.
- The study compared welds created with the dual-speed tool against those made with a conventional tool, finding that the new tool helped mitigate the brittle eutectic phase responsible for cracking.
- Experimental trials identified crucial parameters for high-quality welds, showing that maintaining a minimum material flow rate and controlling the percentage of the weld area exceeding the eutectic temperature lead to defect-free results.
Background: The complement inhibitor CSMD1 acts as a tumor suppressor in various types of solid cancers. Despite its high level of expression in the brain, its function in gliomas, malignant brain tumors originating from glial cells, has not been investigated.
Methods: Three cohorts of glioma patients comprising 1500 patients were analyzed in our study along with their clinical data.