CAR T cells outperform CAR NK cells in CAR-mediated effector functions in head-to-head comparison.

Background: CAR NK cells as vehicles for engineered "off-the-shelf" cellular cancer immunotherapy have attracted significant interest. Nonetheless, a comprehensive comparative assessment of the anticancer activity of CAR T cells and CAR NK cells carrying approved benchmark anti-CD19 CAR constructs is missing. Here, we report a direct head-to-head comparison of CD19-directed human T and NK cells.

Measuring pandemic-related anxiety and confidence in care in chronic patients using the Psychological Consequences of a Pandemic Event (PCPE) questionnaire.

The COVID-19 pandemic has determined a considerable increase in psychological distress worldwide. Compared with the general population, patients with chronic conditions experience higher stress levels due to the increased risk of worse health outcomes from COVID-19 infection. Worries and fear of contagion could cause them to avoid going to their health facilities for medical examinations, which results in higher risks of morbidity and mortality.

It's Time to Run!

Several epidemiological studies have consistently reported inverse associations between cardiorespiratory fitness and the risks of cardiovascular disease and mortality [...

Observation of Light Thermalization to Negative-Temperature Rayleigh-Jeans Equilibrium States in Multimode Optical Fibers.

Although the temperature of a thermodynamic system is usually believed to be a positive quantity, under particular conditions, negative-temperature equilibrium states are also possible. Negative-temperature equilibriums have been observed with spin systems, cold atoms in optical lattices, and two-dimensional quantum superfluids. Here we report the observation of Rayleigh-Jeans thermalization of light waves to negative-temperature equilibrium states.

Interplay of Thermalization and Strong Disorder: Wave Turbulence Theory, Numerical Simulations, and Experiments in Multimode Optical Fibers.

We address the problem of thermalization in the presence of a time-dependent disorder in the framework of the nonlinear Schrödinger (or Gross-Pitaevskii) equation with a random potential. The thermalization to the Rayleigh-Jeans distribution is driven by the nonlinearity. On the other hand, the structural disorder is responsible for a relaxation toward the homogeneous equilibrium distribution (particle equipartition), which thus inhibits thermalization (energy equipartition).