Publications by authors named "A Picca"
Objectives: The present study was conducted to examine the cross-sectional associations between the dietary intake of polyunsaturated fatty acids (PUFAs) and cardiometabolic risk factors in a large sample of Italian community-dwelling older adults.
Methods: This is a cross-sectional study. Longevity Check-up 8+ (Lookup 8+) is an ongoing project that started in June 2015.
Treatment with L-3,4-dihydroxyphenylalanine (L-Dopa) compensates for decreased striatal dopamine (DA) levels and reduces Parkinson's disease (PD) symptoms. However, during disease progression, L-Dopa-induced dyskinesia (LID) develops virtually in all PD patients, making the control of PD symptoms difficult. Thus, understanding the mechanisms underlying LID and the control of these motor abnormalities is a major issue in the care of PD patients.
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- The study investigated how dietary intake of polyunsaturated fatty acids (PUFAs) relates to physical function and sarcopenia in older adults living in Italian communities.
- Researchers assessed participants’ physical capabilities through handgrip strength and sit-to-stand tests, while dietary habits were evaluated via a questionnaire focused on omega-3 and omega-6 fatty acids.
- Findings revealed negative associations between specific types of PUFAs and muscle power/muscle mass but did not show any significant links to sarcopenia, prompting suggestions for further research on dietary impacts in this area.
Down Syndrome (DS) is a genetic disorder caused by the presence of an extra copy of chromosome 21, and leading to various developmental and cognitive defects. A critical feature of DS is the occurrence of oxidative distress particularly in the brain, which exacerbates neurodevelopmental processes. Mitochondria play a crucial role in cell energy metabolism and their impairment is one of the major causes of oxidative distress in several pathologies.
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