Publications by authors named "A Phelan"
Article Synopsis
- - The study investigates how family members support the transition of older relatives into long-term care, focusing on their personal narratives and experiences throughout the process.
- - Four key phases were identified: before transition, crisis event, transition, and after transition, with the 'before transition' phase being the longest due to gradual deterioration of the older relative's health.
- - Understanding these phases and the influence of family dynamics and knowledge can help healthcare providers offer better support and information to families, ultimately easing their emotional burden during this challenging time.
Article Synopsis
- This text discusses the importance of intersectional approaches in climate policy to address the unique health impacts of climate change on women, girls, and gender-diverse individuals, who often face compounded vulnerabilities due to systemic oppression.
- It highlights the lack of meaningful gender and health representation in international climate governance, emphasizing that despite some progress, men still dominate decision-making roles in climate policy.
- The text advocates for promoting gender-responsiveness in climate strategies to enhance inclusivity and effectiveness, leading to more resilient and equitable societies.
Background: EZH2, well-known for its canonical methyltransferase activity in transcriptional repression in many cancers including glioblastoma (GBM), has an understudied non-canonical function critical for sustained tumor growth. Recent GBM consortial efforts reveal complex molecular heterogeneity for which therapeutic vulnerabilities correlated with subtype stratification remain relatively unexplored. Current enzymatic EZH2 inhibitors (EZH2inh) targeting its canonical SET domain show limited efficacy and lack durable response, suggesting that underlying differences in the non-canonical pathway may yield new knowledge.
View Article and Find Full Text PDFBackground: The examination of psychometric properties in instruments measuring abuse of older people (AOP) is a crucial area of study that has, unfortunately, received relatively little attention. Poor psychometric properties in AOP measurement instruments can significantly contribute to inconsistencies in prevalence estimates, casting a shadow of uncertainty over the magnitude of the problem at national, regional, and global levels.
Objectives: This review rigorously employed the Consensus-based Standards for the Selection of Health Measurement Instruments (COSMIN) guideline on the quality of outcome measures.