Publications by authors named "A Phadte"
Introduction: Differentiating pheochromocytomas from other adrenal masses based on computed tomography (CT) characteristics remains challenging, particularly in lipid-poor lesions with variable washout patterns. This study evaluated CT features for distinguishing pheochromocytomas in good and poor washout subcohorts.
Methods: We prospectively analyzed 72 patients with unilateral lipid-poor adrenal masses.
Purpose: Data on the polar vessel sign (enlarged feeding vessel terminating in parathyroid lesions) on four-dimensional computed tomography (4D-CT) is limited. We performed a retrospective analysis to determine the prevalence, predictors, and adjunctive utility of polar vessel sign in pre-operative 4D-CT of patients with primary hyperparathyroidism (PHPT).
Methods: One radiologist blinded to the patients' details reported the 4D-CT of eighty-four operated patients with histopathology-proven single-gland PHPT.
Article Synopsis
- FAN1 is a crucial DNA-dependent nuclease necessary for human health, and mutations in this gene can influence the onset of diseases like Huntington's.
- The Arg507His mutation in FAN1 disrupts its interaction with PCNA, leading to decreased assembly on problematic DNA structures associated with disease.
- This mutation significantly impairs FAN1’s ability to cleave these DNA extrusions, highlighting the essential role of PCNA in maintaining genomic stability through FAN1 function.
Article Synopsis
- * Sensitivity for tumor identification was similar across contrast-enhanced CT (CECT) and two types of PET scans (SSTR and FDG), but notably low for DOPA-PET, while CECT showed better results for specific tumors like Thymic NET.
- * SSTR-PET/CT is recommended as the preferred imaging method due to its lower false positive rate, although a significant number of tumors (about 25%) in patients remain undetected with current methods, indicating a need for further research.
Objective: Lipoid congenital adrenal hyperplasia (LCAH) is caused by mutations in STAR. A systematic review of phenotype-genotype correlation and data on testicular histology in LCAH patients is unavailable. We aim to describe our experience and provide phenotype-genotype correlation.
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