Publications by authors named "A Pezzotta"
Gamma-oryzanol (ORY), found in rice ( L.), is a mixture of ferulic acid esters with triterpene alcohols, well-known for its antioxidant and anti-inflammatory properties. Our past research demonstrated its positive impact on cognitive function in adult mice, influencing synaptic plasticity and neuroprotection.
View Article and Find Full Text PDFArticle Synopsis
- * Among the leukemias, acute myeloid leukemia (AML) is highly aggressive with poor survival rates, especially in patients with specific gene mutations, while hairy cell leukemia (HCL) remains rare and untreated with approved drugs.
- * New epigenetic therapies, particularly histone deacetylase (HDAC) inhibitors, show promise in targeting blood cancers, with new hydroxamic acid derivatives demonstrating effectiveness in inducing cell death and improving outcomes in models of AML and other blood cancers.
Deficiency of adenosine deaminase 2 (DADA2) is an inborn error of immunity caused by loss-of-function mutations in the adenosine deaminase 2 (ADA2) gene. Clinical manifestations of DADA2 include vasculopathy and immuno-hematological abnormalities, culminating in bone marrow failure. A major gap exists in our knowledge of the regulatory functions of ADA2 during inflammation and hematopoiesis, mainly due to the absence of an ADA2 orthologue in rodents.
View Article and Find Full Text PDF