Publications by authors named "A Petrie"
Importance: Transthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive cardiomyopathy that commonly presents with concomitant chronic kidney disease. Chronic kidney dysfunction is associated with worse outcomes, but the prognostic value of changes in kidney function over time has yet to be defined.
Objective: To assess the prognostic importance of a decline in estimated glomerular filtration rate (eGFR) in a large cohort of patients with ATTR-CM.
Article Synopsis
- The article reviews the effects of recreational drug use, specifically cannabis and opioids, on musculoskeletal health and bone density in patients with chronic pain.
- A total of 55 studies were analyzed, showing that these substances negatively impact bone maintenance by affecting bone cell activity and hormone production, leading to lower bone density and higher fracture risk.
- The authors conclude that while there is evidence of harm from recreational drugs on bone health, more research is needed to understand long-term effects and to improve treatment plans for those using these substances.
Article Synopsis
- Cardiac amyloid infiltration significantly impacts survival in systemic light-chain (AL) amyloidosis, with guidelines suggesting early therapy changes for patients not responding well, regardless of cardiac amyloid severity.
- The study aimed to compare serum biomarkers, echocardiography, and cardiovascular magnetic resonance (CMR) with extracellular volume (ECV) mapping in understanding cardiac amyloid and its prognostic value.
- Findings revealed that ECV is a strong independent predictor of mortality, showing different relationships between the depth of hematological response and survival based on specific ECV thresholds over 1- and 6-month periods.
Objective To evaluate the survival and clinical performance of restorative materials used in the rehabilitation of generalised severe tooth wear within a UK NHS postgraduate teaching hospital.Methods The clinical performance of 527 restorations on 20 patients with generalised severe tooth wear was reviewed after a mean period of five years. Anterior teeth were restored with direct composite resin and posterior teeth with indirect restorations.
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- This study aims to enhance the NAC staging system for transthyretin cardiac amyloidosis (ATTR-CA) by adding a new stage to better identify patients at high risk of early death.
- A new stage 4 was introduced based on NT-proBNP levels (≥10,000 ng/L), and results from 2042 patients showed significantly higher mortality rates for this group compared to lower stages.
- The findings suggest that patients in stage 4 may need more intensive treatment strategies due to their elevated risk of early mortality, which could also inform clinical trial designs.