Publications by authors named "A Petelski"
Article Synopsis
- Pre-patterning in embryo development is common in non-mammalian species, but mammals were thought to lack this due to their regulative development, which randomly contributes to the three blastocyst lineages.
- Recent studies show that early blastomeres in mouse and human embryos actually have distinct developmental fates and differences in protein levels, challenging the previous notion of randomness.
- Utilizing advanced proteomics, researchers found that 2-cell embryos contain alpha and beta blastomeres with different protein abundances linked to their developmental potential, with beta blastomeres more likely to produce higher amounts of epiblast cells.
Ammeline (AM) is a molecule with a very low reputation in the field of supramolecular community, but with a recently proven potential both experimentally and theoretically. In this work, dispersion-corrected density functional theory (DFT-D) computations and molecular dynamics (MD) simulations were employed to understand the aggregation mechanism of AM in chloroform and water media. Our DFT-D and MD analyses show that the most important interactions are those formed by the amine groups (-NH) with both the pyridine-type nitrogen atoms and the carbonyl groups (C=O).
View Article and Find Full Text PDFAdvanced maternal age is associated with a decline in oocyte quality, which often leads to reproductive failure in humans. However, the mechanisms behind this age-related decline remain unclear. To gain insights into this phenomenon, we applied plexDIA, a multiplexed, single-cell mass spectrometry method, to analyze the proteome of oocytes from both young women and women of advanced maternal age.
View Article and Find Full Text PDFAdvanced maternal age is associated with a decline in oocyte quality, which often leads to reproductive failure in humans. However, the mechanisms behind this age-related decline remain unclear. To gain insights into this phenomenon, we applied plexDIA, a multiplexed data-independent acquisition, single-cell mass spectrometry method, to analyze the proteome of oocytes from both young women and women of advanced maternal age.
View Article and Find Full Text PDFIsomorphic substitution of zeolites with B, Al and Ga is a widely used approach in catalysis. The experimentally reported trend of their acidities decreases in the order: Al>Ga>B. However, a consistent explanation is still lacking in the literature.
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