Publications by authors named "A Pessina"
Background: Hypomorphic mutations in the () gene cause a glycosylation disorder that leads to immunodeficiency. It is often associated with recurrent infections and atopy. The exact etiology of this condition remains unclear.
View Article and Find Full Text PDFTherapies based on mesenchymal stromal cells (MSCs) have become one of the most significant advancements in veterinary regenerative medicine. The isolation of MSCs is usually performed by enzymatic digestion and requires variable times for cell expansion. In addition, these procedures need to be performed in specialized laboratory facilities.
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- Pleural mesothelioma (PM) is a rare cancer closely associated with asbestos exposure, currently lacking effective treatment options, leading to a poor prognosis.
- The study explores using mesenchymal stromal cells (MSCs) to deliver the chemotherapy drug Paclitaxel (PTX) directly to the pleural cavity, aiming to enhance drug concentration at the tumor site while reducing side effects.
- The PACLIMES trial assesses the safety and toxicity of this local PTX administration in patients eligible for surgery, with a goal to identify the effective dose for future studies and evaluate its anti-tumor effects.
Adipose tissue is mainly composed by adipocytes. Moreover, mesenchymal stromal/stem cells (MSCs), macrophages, endothelial cells, and extracellular matrix components are present. The variety of molecules as cytokines and growth factors of its structure very rich in blood vessel makes it also similar to a true endocrine organ that however needs still to be fully investigated.
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