Background: Dietary recommendations have globally shifted towards promoting the consumption of legumes as an environmentally friendly and healthy source of protein. This study investigated the replacement of red and processed meat, poultry or fish for equal amounts of legumes on the risk of non-alcoholic fatty liver disease (NAFLD).
Methods: UK Biobank participants who completed ≥ 2 dietary assessments and had complete covariate information were included in the analyses (N = 124,546).
: Nutrimetabolomics may reveal novel insights into early metabolic alterations and the role of dietary exposures on prostate cancer (PCa) risk. We aimed to prospectively investigate the associations between plasma metabolite concentrations and PCa risk, including clinically relevant tumor subtypes. : We used a targeted and large-scale metabolomics approach to analyze plasma samples of 851 matched PCa case-control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.
View Article and Find Full Text PDFBackground: Adiposity is positively associated with risk of some cancer sites and other health conditions in men; however, it is unclear if endogenous hormones play a role in these associations. We examined how body composition, measured from magnetic resonance imaging (MRI) and common measures of adiposity (e.g.
View Article and Find Full Text PDFBackground: Fruit consumption has been associated with a lower cardiovascular disease (CVD) risk but the underlying mechanisms are unclear. We investigated the cross-sectional and prospective associations of fruit consumption with markers of adiposity, blood pressure, lipids, low-grade inflammation, glycaemia, and oxidative stress.
Methods: The main analyses included 365 534 middle-aged adults from the UK Biobank at baseline, of whom 11 510, and 38 988 were included in the first and second follow-up respectively, free from CVD and cancer at baseline.