Publications by authors named "A Pels"
Article Synopsis
- Early-onset fetal growth restriction affects roughly 0.3% of pregnancies and is linked to increased risks such as early-onset pre-eclampsia, with the aim of improving predictions for perinatal mortality.
- This analysis examined data from 215 pregnant women with severe early-onset fetal growth restriction, utilizing logistic regression to identify predictors of perinatal mortality.
- Key predictors of perinatal mortality included fetal abdominal circumference, gestational age at diagnosis, estimated fetal weight, and umbilical artery measurements; the treatment randomization did not influence mortality risk.
Article Synopsis
- Fetal growth restricted (FGR) pregnancies may lead to increased risk of cardiovascular and renal diseases in offspring, prompting investigations into the use of sildenafil for improved fetal growth.
- In a study from the Dutch STRIDER trial involving HUVECs and placental samples, no significant differences in cardiovascular or renal gene expression were found between sildenafil and placebo groups.
- Although sildenafil did not affect fetal programming, it did alter some immune-related gene expressions in placental tissue, suggesting a specific action rather than a broad benefit for cardiovascular or renal health in FGR pregnancies.
Introduction: In early-onset fetal growth restriction the fetus fails to thrive in utero due to unmet fetal metabolic demands. This condition is linked to perinatal mortality and severe neonatal morbidity. Maternal administration of corticosteroids in high-risk pregnancies for preterm birth at a gestational age between 24 and 34 weeks has been shown to reduce perinatal mortality and morbidity.
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- Fetal growth restriction (FGR) is when a baby doesn’t grow well in the womb, and one cause is problems with the placenta, which is like the baby's lifeline.
- Severe FGR can happen in about 1 in 250 pregnancies, and it can lead to serious risks for the baby, so doctors try to deliver the baby early to keep it safe.
- This study looks at different treatments that can help improve blood flow to the placenta using a method that works with nitric oxide, to see if they are safe and effective for mothers with severe early-onset FGR.