Publications by authors named "A Peloso"
Article Synopsis
- Neurocritical illnesses often lead to increased mortality in low-resource countries, and early neurodeterioration (END) may help identify high-risk patients for better care.
- A study conducted in Zambia monitored neurology inpatients to assess the impact of END, defined as a decline in the Glasgow Coma Scale (GCS) within three days of admission.
- The results showed that 18% of patients experienced END, significantly increasing their risk of death (72% vs 11% mortality), with common causes of death being aspiration pneumonia and sepsis, indicating a need for targeted interventions.
Trimming the fat myth: adipose tissue's role in liver regeneration.
Hepatobiliary Surg Nutr
August 2024
Article Synopsis
- Decellularized ECM bioscaffolds are being explored as a new 3D model for studying radiation effects on cancer cells, specifically radioresistant cell lines HMV-II and PANC-1.
- The study involved irradiating these cells in porcine liver-derived scaffolds with high- and low-energy radiation to evaluate their biological responses in a more realistic in vivo-like environment.
- Results showed that cells maintained their specific characteristics and responded differently to high LET radiation, with Carbon Ions causing more significant damage than photons, indicating that these bioscaffolds could be valuable for future radiobiological research.
Background: Pancreatic islet transplantation for type 1 diabetes mellitus (T1DM) is efficacious in supressing severe hypoglycaemic episodes (SHE) and restoring glycaemic regulation, which are both pivotal in increasing health-related quality of life (HRQoL). Therefore, a systematic assessment of reports detailing HRQoL outcomes is warranted to better understand the benefits of islet transplantation. To this end, we performed a systematic review of the literature to assess the impact of islet transplantation on HRQoL in individuals with T1DM, whether as a standalone procedure (ITA) or following renal transplantation (IAK).
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- Maternal obesity has been linked to a higher risk of hepatocellular carcinoma (HCC) in offspring, and this study explores the mechanisms behind this connection.
- Female mice were fed either a high-fat diet or a normal diet, and their offspring were studied for liver health and tumor development after being induced with HCC.
- Results showed that offspring from obese mothers had more liver diseases and tumors, linked to changes in gut microbiome, suggesting that gut health may play a critical role in developing these conditions.