MR1-restricted T (MR1T) cells recognize microbial small molecule metabolites presented on the MHC Class I-like molecule MR1 and have been implicated in early effector responses to microbial infection. As a result, there is considerable interest in identifying chemical properties of metabolite ligands that permit recognition by MR1T cells, for consideration in therapeutic or vaccine applications. Here, we made chemical modifications to known MR1 ligands to evaluate the effect on MR1T cell activation.
View Article and Find Full Text PDFJ Eur Acad Dermatol Venereol
August 2022
The percentage of complications following an interval or emergency operative interventions in the abdomen is different and depends on several factors: -Proper indication for surgery -Experience of the surgical team, anesthesia -Extent of pathological changes; -patient's general condition (presence of associated diseases, capacity of the cardiovascular system, a.o.).
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