Publications by authors named "A Pazzola"
Background: MAURIS is an Italian multicenter, open-label, phase IIIb ongoing trial, aiming at evaluating the safety and effectiveness of atezolizumab + carboplatin/etoposide in patients with newly diagnosed, extensive-stage small-cell lung cancer (ES-SCLC). The primary objective is the safety evaluation.
Materials And Methods: Patients received atezolizumab + carboplatin/etoposide Q3W for 4-6 cycles in the induction phase, followed by atezolizumab maintenance Q3W.
Article Synopsis
- The study investigates how specific genetic variations (SNPs) in the aromatase gene influence the effectiveness and side effects of aromatase inhibitors like letrozole in postmenopausal women with estrogen receptor-positive breast cancer.
- The research involved 886 participants and found that while no SNPs were linked to disease-free survival, certain variations were associated with a higher risk of breast cancer metastasis and overall survival rates.
- The findings suggest that understanding these genetic variations could help personalize treatment strategies for patients undergoing therapy for ER+ early breast cancer.*
Lung cancer is one of the most common and lethal cancers worldwide. Numerous medications targeting specific molecular alterations in non-small cell lung cancer have been introduced in the last decade and have revolutionized the clinical management of the disease. Their use has brought to a parallel evolution of molecular testing techniques to identify alterations in druggable molecular targets within the genetic material of the tumors.
View Article and Find Full Text PDFBackground: Adjuvant chemotherapy is recommended in high-risk breast cancer. However, no universally accepted guidelines exist on pre-chemotherapy assessment. In particular, the number and frequency of medical visits vary according to each institution's policy.
View Article and Find Full Text PDFEffectiveness of a Psychosocial Care Quality Improvement Strategy to Address Quality of Life in Patients With Cancer: The HuCare2 Stepped-Wedge Cluster Randomized Trial.
JAMA Netw Open
October 2021
Article Synopsis
- A significant number of cancer patients miss out on vital psychosocial care, which is crucial for their overall well-being, and effective integration into healthcare practices is essential for improving patient outcomes.
- The study aimed to compare the effects of the Humanization in Cancer Care (HuCare) Quality Improvement Strategy against standard care on enhancing either emotional or social functions in patients' quality of life over a 3-month period.
- Conducted across multiple cancer centers in Italy, the trial included various interventions like clinician communication training and evidence-based recommendations, with results showing an enrollment of 762 patients and tracked improvements in psychosocial aspects of care.