Publications by authors named "A Paya Roma"
Endometrial mucinous carcinoma of the gastric [gastrointestinal] type (MCG) is a rare, possibly aggressive subtype of endometrial cancer that should be distinguished from its potential mimics, including endometrioid carcinoma (EEC). Herein, we assess the frequency of gastric and gastrointestinal immunophenotypes in EEC without any discernible gastric/gastrointestinal-type morphology. Immunohistochemical analyses for KRT(CK)7, KRT20, CDX2, ER, SATB2, MUC6, PAX8, and HIK1083 were performed on 81 EEC, inclusive of consecutively archived low grade [with (n = 22) and without (n = 47) mucinous differentiation] and high grade (n = 12) cases.
View Article and Find Full Text PDFPresence and extent of lymphovascular invasion in surgical stage I squamous cell carcinoma of the cervix: a comprehensive, international, multicentre, retrospective clinicopathological study.
Pathology
February 2025
The aim of this study was to determine whether the presence and extent of lymphovascular invasion (LVI) is prognostic in surgical stage I cervical squamous cell carcinoma (SCC). All available tumour slides and/or paraffin blocks from 426 patients with stage I cervical SCC treated surgically with curative intent were collected from 18 institutions and retrospectively analysed. Presence and extent of LVI (focal <5 spaces, extensive ≥5 spaces) were assessed on scanning magnification in large haematoxylin and eosin slide sets in 366 cases.
View Article and Find Full Text PDFArticle Synopsis
- Cardiac arrest (CA) is a critical condition, and survivors often experience post-cardiac arrest syndrome (PCAS), making echocardiograms essential for evaluating their condition.
- The study reviews existing literature to highlight the significance of transthoracic and transesophageal echocardiograms during and after cardiac arrest.
- The conclusion emphasizes that these echocardiogram techniques play crucial roles in diagnosing and predicting outcomes for patients during the CA phase and beyond.
Article Synopsis
- Heart failure (HF) and atrial fibrillation (AF) are common and serious heart-related conditions that lead to increased health issues, hospital visits, and healthcare costs.
- These two diseases often occur together and influence each other, especially through the damaging effects of oxidative stress caused by reactive oxygen species (ROS), which can worsen heart structure and function.
- New medications for heart failure also help manage atrial fibrillation by reducing oxidative stress, and this review focuses on how these treatments can prevent and improve AF in patients with HF.
Purpose: Small-cell lung cancer (SCLC) is an aggressive disease with a dismal prognosis. The addition of immune checkpoints inhibitors to standard platinum-based chemotherapy in first-line setting achieves a durable benefit only in a patient subgroup. Thus, the identification of predictive biomarkers is an urgent unmet medical need.
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