Comparative Efficacy of Nonsteroid Immunosuppressive Medications in Childhood Nephrotic Syndrome.

Importance: Cyclophosphamide and calcineurin inhibitors are the most used nonsteroid immunosuppressive medications globally for children with various chronic inflammatory conditions. Their comparative effectiveness remains uncertain, leading to worldwide practice variation. Nephrotic syndrome is the most common kidney disease managed by pediatricians globally and suboptimal treatment is associated with high morbidity.

Barriers and enablers to measuring resting metabolic rate in the high-performance sporting system: A qualitative exploratory study.

Measurements of resting metabolic rate (RMR) may be undertaken for dietary planning purposes or to assess for low energy availability (LEA). This study investigated barriers and enablers to measuring RMR in real-world, high-performance sport environments. Twelve interviews were conducted with technicians ( = 6 dietitians,  = 6 physiologists) employed across six National Institute Networks, two National Sporting Organisations and one professional sporting code.

Effects of 24-Hour Diet- or Exercise-Induced Energy Availability Manipulations on Substrate Utilization and Performance.

Purpose: To examine sex-based differences in substrate oxidation, postprandial metabolism, and performance in response to 24-hour manipulations in energy availability (EA), induced by manipulations to energy intake (EI) or exercise energy expenditure (EEE).

Methods: In a Latin Square design, 20 endurance athletes (10 females using monophasic oral contraceptives and 10 males) undertook five trials, each comprising three consecutive days. Day one was a standardized period of high EA; EA was then manipulated on day two; post-intervention testing occurred on day three.

Ethyl 4-[(2-hy-droxy-eth-yl)amino]-2-(4-meth-oxyphen-yl)-1-methyl-5-oxo-2,5-di-hydro-1-pyrrole-3-carboxyl-ate.

In the title compound, CHNO the pyrrolidine ring is almost planar and subtends a dihedral angle of 85.77 (7)° with the pendant phenyl ring. An intra-molecular N-H⋯O hydrogen bond generates an (6) loop.

Randomized controlled trial of cognitive behavioral therapy versus health education for sleep disturbance and fatigue following stroke and traumatic brain injury.

Objective: Evaluate efficacy of cognitive behavioural therapy for sleep and fatigue adapted for brain injury relative to health education control in alleviating sleep disturbance and fatigue after acquired brain injury.

Design: Parallel groups randomized controlled trial.

Subjects: 126 community dwelling adults with stroke or traumatic brain injury.