Publications by authors named "A Pattison"
Article Synopsis
- Ferroelectric HfO-based thin films are being researched for their potential in advanced electronic devices, but understanding their ferroelectric properties at the nanoscale remains a challenge due to their complex structures.
- Recent studies using electron microscopy techniques have detailed the in-plane domain structures of Y:HfO films, revealing how their unique grain boundaries and phases contribute to their ferroelectricity.
- Key findings show that specific orientations and patterns within the grain structures enhance polarization, and the behavior of domain walls affects the overall ferroelectric performance depending on their alignment and thickness of the films.
Article Synopsis
- Hereditary mutant pheochromocytomas (PC) and paragangliomas (PG) are rare tumors that tend to metastasize unpredictably, prompting a study to better understand their genomic characteristics.
- A multi-omic analysis of 94 tumors from 79 patients revealed distinct molecular profiles based on whether the tumors originated from sympathetic or parasympathetic cells, with specific alterations linked to metastatic behavior.
- The study also identified high mutation loads, unusual genomic features, and mechanisms of resistance to DNA alkylating chemotherapies, enhancing the comprehension of these complex neuroendocrine tumors and their treatment responses.
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View Article and Find Full Text PDFWhile digital innovation in health was already rapidly evolving, the COVID-19 pandemic has accelerated the generation of digital technology tools, such as chatbots, to help increase access to crucial health information and services to those who were cut off or had limited contact with health services. This theme issue titled "Chatbots and COVID-19" presents articles from researchers and practitioners across the globe, describing the development, implementation, and evaluation of chatbots designed to address a wide range of health concerns and services. In this editorial, we present some of the key challenges and lessons learned arising from the content of this theme issue.
View Article and Find Full Text PDFEndobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is often the only source of tumor tissue from patients with advanced, inoperable lung cancer. EBUS-TBNA aspirates are used for the diagnosis, staging, and genomic testing to inform therapy options. Here we extracted DNA and RNA from 220 EBUS-TBNA aspirates to evaluate their suitability for whole genome (WGS), whole exome (WES), and comprehensive panel sequencing.
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