Publications by authors named "A Pastorczak"
Article Synopsis
- - Acute lymphoblastic leukaemia (ALL) is a complex pediatric cancer that requires precise diagnostics to ensure effective treatment, especially in distinguishing between B-cell ALL (B-ALL) and T-cell ALL (T-ALL).
- - This study investigates the use of label-free Raman imaging with chemometrics as a rapid testing method for accurately identifying and classifying B-ALL and T-ALL at the single-cell level, showing significant improvements over traditional methods.
- - Findings reveal that Raman spectroscopy detects unique molecular signatures in leukemic cells, allowing for reliable differentiation from normal lymphocytes, and highlights its potential for enhancing clinical diagnosis and personalized treatment strategies in pediatric oncology.
Chromothripsis (cth) is a form of genomic instability leading to massive de novo structural chromosome rearrangements in a one-time catastrophic event. It can cause cancer-promoting alterations, such as loss of sequences for tumor-suppressor genes, formation of oncogenic fusions, and oncogene amplifications. We investigated the genetic background and clinical significance of cth in childhood T-cell acute lymphoblastic leukemia (T-ALL) patients.
View Article and Find Full Text PDFAtaxia-telangiectasia (A-T) is an autosomal-recessive disorder caused by pathogenic variants (PVs) of the ATM gene, predisposing children to hematological malignancies. We investigated their characteristics and outcomes to generate data-based treatment recommendations. In this multinational, observational study we report 202 patients aged ≤25 years with A-T and hematological malignancies from 25 countries.
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