Publications by authors named "A Pasquini"
Article Synopsis
- Aortic valve replacement (AVR) has seen an increased use of the Perceval sutureless bioprosthesis, which shows promising safety and reliability in both short- and mid-term outcomes, with some long-term data emerging.
- An updated systematic review of studies from 2015 to 2024 analyzed long-term outcomes of 5,221 patients with Perceval implants, revealing a long-term survival rate between 64.8% to 87.9% and low rates of complications such as structural valve degeneration and significant leaks.
- Despite limited data on sutureless bioprostheses, the encouraging results from existing studies suggest that Perceval could provide
Polyethylene-glycolated -derived l-asparaginase (pegaspargase, pASP) is an essential component of paediatric-inspired regimens for the treatment of acute lymphoblastic leukaemia/lymphoma; nonetheless, is characterised by severe and potentially life-threatening toxicities, such as hypertriglyceridemia. Grades 3-4 events have been reported in ~1%-18% of paediatric patients and in sparse reports in adults. There is limited evidence on the safety of asparaginase rechallenge in patients experiencing severe pASP-related hypertriglyceridemia.
View Article and Find Full Text PDFAtrial fibrillation (AF) is the most common cardiac sustained arrhythmia, and it is associated with increased stroke and dementia risk. While the established paradigm attributes these complications to blood stasis within the atria and subsequent thrombus formation with cerebral embolization, recent evidence suggests that atrial myopathy (AM) may play a key role. AM is characterized by structural and functional abnormalities of the atria, and can occur with or without AF.
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